The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking oxytocin. Oxytocin is a hormone made naturally in the body. The investigators will also examine the impact of any anxiety, depression, and stress related symptoms on learning processes.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborator: United States Department of Defense
• Treatments: Oxytocin

Criteria

Inclusion Criteria:

• Men or women 18 to 65 years of age

• Score in study range on the Neuroticism-Extraversion-Openness-Five Factor Inventory (NEO-FFI)

• No current Axis I Diagnostic and Statistical Manual-IV (DSM) excluded diagnoses as determined by the Structured Clinical Interview DSM (SCID) completed within the past 4 months.

• Must be able and willing to understand study procedures and return to the clinic on two separate consecutive days for the fear-conditioning procedures.

• Subjects must be able to give informed consent and be willing and able to comply with study procedures.

Exclusion Criteria:

• Presence of a current DSM-IV Axis I diagnosis as measured by the SCID.

• A serious medical condition or other condition deemed likely to result in surgery or hospitalization, or which would make participation in the study difficult.

• Patients with a history of trauma resulting in head injury related seizures or with epilepsy (except a prior history of febrile seizures of infancy which are not exclusionary).

• Use of supplemental hormones (birth control, estrogen, testosterone, prednisone, etc) or narcotics.

• Pregnant or lactating women.

• Women of childbearing potential not using medically accepted forms of contraception.

• Current use of the excluded psychiatric medications.

• Known hypersensitivity to oxytocin

• Known hyponatremia.