The Effect of PERT on Patients Undergoing Pancreaticoduodenectomy

• Status: Recruiting
• Trial end date: 2025-12-31
• Target enrollment: 0
• Participant gender: All

Summary

A comprehensive perioperative nutrition management plan for pancreaticoduodenectomy, primarily based on pancreatic enzyme replacement therapy (PERT). A prospective randomized controlled study was conducted to comprehensively analyze the perioperative nutritional status of patients undergoing pancreaticoduodenectomy, with the aim of exploring:

1. The effect of PERT on postoperative complications and physiological status after pancreaticoduodenectomy;

2. The efficacy of PERT treatment on clinical symptoms, nutritional indicators, and quality of life (QOL) related to pancreatic exocrine dysfunction (PEI) after pancreaticoduodenectomy;

3. The personalized full process nutrition management strategies based on risk factor stratification.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ruijin Hospital
• Treatments: Pancreatin; Pancrelipase

Criteria

Inclusion Criteria:

• Gender unlimited, 18-80 years old;

• Patients undergoing pancreaticoduodenectomy due to various benign or malignant diseases;

• Voluntary testing with informed consent.

Exclusion Criteria:

• Pregnant women and lactating women

• Patients with distant metastasis based on tumor staging before surgery;

• Tumor recurrence;

• Refuse to sign the consent form.