The Effect of Pre-operative Use of Finasteride Versus Cyproterone Acetate on Blood Loss With Transurethral Resection of Prostate

• Status: Completed
• Trial end date: 2020-07-09
• Target enrollment: 0
• Participant gender: Male

Summary

Perioperative bleeding is the most common complication related to transurethral resection of prostate, the aim of the study is to compare the effect of pre-operative use of finasteride versus Cyproterone acetate on blood loss with mono polar TURP

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Benha University
• Treatments: Cyproterone; Cyproterone Acetate; Finasteride

Criteria

Inclusion Criteria:

• Patients with benign prostatic hyperplasia with prostate size (60-100) grams

• Lower urinary tract symptoms (LUTS) not responding to medical treatment

• Recurrent prostatic bleeding

• Recurrent acute urinary retention

• Chronic urinary retention

Exclusion Criteria:

• Patients with coagulation disorders

• Previous prostatic surgery

• Previous finasteride administration

• Bladder pathology (urinary bladder stones - bladder mass)

• Suspected or proved cancer prostate

• Hepatic or renal impairment

• Patients unfit for operation eg. Decompensated heart failure, poor chest condition