The Effect of Preoperative Aminophylline

• Status: Unknown status
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Several clinical studies and case reports suggested that aminophylline antagonizes the effects of diazepam , barbiturates , sevoflurane ,morphineand propofol.However, the available results from uncontrolled clinical settings make it difficult to quantify the specific effects of aminophylline on hypnotics and anesthetics

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Beni-Suef University
• Treatments: Aminophylline

Criteria

Inclusion Criteria:

• Patients age: 20-60 years

• Males and females patients

• American Society Of Anesthesiology (ASA) physical status I- II .

Exclusion Criteria:

• Patient refusal to participate in this study

• Patient with known sensitivity to aminophylline

• Patients with history of cardiac failure

• Patients with renal or hepatic dysfunction and in chronic alcoholism since clearance of aminophylline is decreased.

• Patients with peptic ulcer, hyperthyroidism, glaucoma,as these conditions may be exacerbated.

• Patients with opioid addiction

• Current treatment with B agonists, anticholinergic agents, tranquilizers, anticonvulsants ,or antidepressants.

• Pregnancy.

• Habitual coffee consumption exceeding 2 cups per day.