The Effect of Preoperative Oral Dexamethasone Supplementation on the Outcome of Thyroidectomised Patients.
Status:
Recruiting
Trial end date:
2022-03-01
Target enrollment:
Participant gender:
Summary
Glucocorticoids are well known for their analgesic, anti-inflammatory, immunomodulatory and
anti-emetic effects. Recovery time after thyroid surgery may depend on several factors, such
as postoperative pain, nausea and vomiting, postoperative sore throat, voice disorders and
symptomatic hypocalcaemia (low serum calcium level). However, there is little information in
the literature about the preventive use of glucocorticosteroids in patients undergoing
thyroid surgery. The aim of the study is to evaluate the clinical impact of preoperative oral
dexamethasone supplementation on the surgical outcome in patients with multinodular goiter
undergoing total thyroidectomy. Patients will be assigned to the supplementation group and
the placebo group. In the supplementation group 8mg of dexamethasone will be administered
orally one hour before surgery. In the postoperative period, the frequency and intensity of
pain, nausea, vomiting, sore throat and hoarseness will be assessed. The incidence of
symptoms of hypocalcaemia will also be evaluted. Preoperative and postoperative levels of
vitamin D, cytokines, acute phase proteins and substances related to calcium metabolism will
be measured in the blood. Cytokines levels in drainage fluid will also be assessed. The main
hypothesis of the study is that in patients with supplementation postoperative discomfort and
decrease in serum calcium and parathormone level and hypocalcemic symptoms will be less
severe and the levels of proinflammatory substances will be decreased.
Phase:
Phase 4
Details
Lead Sponsor:
Medical University of Lodz Medical Universtity of Lodz