The Effect of Probiotics on Asthma Risk in Animal Laboratory Workers

• Status: Unknown status
• Trial end date: 2020-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This project will be test the effect of probiotics on occupational allergic sensitization, respiratory symptoms and bronchial hyperresponsiveness in workers or students that develop respiratory symptoms exposed to laboratory animals, i.e., small rodents.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Sao Paulo
• Collaborator: University of Sao Paulo General Hospital

Criteria

Inclusion Criteria:

• Older than 18 years, both sexes, ability to read, understand and to decide on protocol consenting.

• Participants should be healthy

• Animal handling for research purposes as part of regular activities as a worker or student.

• Planning to continue this activity for the next 2 years.

Exclusion Criteria:

• Previous laboratory animal handling for 15 days or longer. This exposure may have sensitized or selected people that are not susceptible to sensitizations.

• Sensitization to any laboratory animal (rat, mouse, hamster, guinea pig or rabbit).

• Allergic diseases that interfere with the evaluation of study variables.

• Using immunosuppressive drugs (ex: methotrexate, cyclosporine, leflunomide) or corticosteroids in immunosuppressive doses (e.g.: prednisone doses of 1.0 mg/kg/day or more).

• Cancer or treatment of neoplasia.

• Having diseases that cause immunosuppression such as diabetes, AIDS, renal failure, heart failure or other organ failure.

• Pregnancy, breastfeeding, or not willing to take necessary precautions to avoid a pregnancy during the study.

• Use of other probiotic products during the study.