The Effect of Probiotics on Microbial Translocation and Inflammation in HIV-infected Patients

• Status: Completed
• Trial end date: 2016-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Objective:

In this study the investigators aim at investigating:

1. probiotics ability to modulate the microbiome and microbial translocation,

2. if probiotics affect the level of cholesterol, triglycerides as markers of cardiovascular risk factors and

3. if a reduction of microbial translocation is associated with a reduction of inflammation in the gastro-intestinal tract.

Design:

The study is a prospective clinical intervention trial of 40 HIV-infected patients.

Method:

The investigator will administer the bacteria Lactobacillus Rhamnosus in capsular form to each patient 2 times a day in 8 weeks. At baseline and at the 8th week of the intervention, the investigators will collect blood samples, feces samples and make a positron emission tomography-magnetic resonance scans.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark

Criteria

Inclusion Criteria:

• age over 18

• confirmed HIV

• no HIV treatment

• cluster of differentiation 4+ cell count over 350

Exclusion Criteria:

• antibiotic or probiotic in last 2 month

• drugs that influence gut motility

• diabetes

• Inflammatory bowel disease

• cancer

• autoimmune diseases