The Effect of Probiotics on Microbial Translocation and Inflammation in HIV-infected Patients
Status:
Completed
Trial end date:
2016-09-01
Target enrollment:
Participant gender:
Summary
Objective:
In this study the investigators aim at investigating:
1. probiotics ability to modulate the microbiome and microbial translocation,
2. if probiotics affect the level of cholesterol, triglycerides as markers of
cardiovascular risk factors and
3. if a reduction of microbial translocation is associated with a reduction of inflammation
in the gastro-intestinal tract.
Design:
The study is a prospective clinical intervention trial of 40 HIV-infected patients.
Method:
The investigator will administer the bacteria Lactobacillus Rhamnosus in capsular form to
each patient 2 times a day in 8 weeks. At baseline and at the 8th week of the intervention,
the investigators will collect blood samples, feces samples and make a positron emission
tomography-magnetic resonance scans.