The Effect of Proprioception of Platelet Rich Plasma for Patients With Ankle Sprain
Status:
Recruiting
Trial end date:
2020-12-06
Target enrollment:
Participant gender:
Summary
Ankle sprain is a fairly common sports medicine clinic. In Taiwan at least 150,000 to 200,000
people will suffer from ankle sprains every years. Clinicians have been looking for ways to
shorten treatment time and reduce discomfort. Platelet Rich Plasma(PRP) is an endogenous
therapeutic technology that involved in regenerative medicine due to its potential to
stimulate and accelerate tissue healing. PRP can release lots of growth factors like
platelet-derived growth factor (PDGF),transforming Growth Factor Beta(TGF-β), vascular
endothelial growth factor(VEGF),Epidermal growth factor(EGF) and insulin-like growth factor
(IGF). Its use had been based on the theory that increased autologous platelets, that then
yield high concentrations of growth factors and other proteins, will lead to increased
healing of tendon and soft tissue on a cellular level. In addition, there is no objective
evaluation after treatment, so that patients can not provide effective and accurate
quantitative feedback. In this study, the investigators divided patients into three groups,
respectively, general rehabilitation therapy, autologous PRP injection therapy, autologous
PRP injection combined with general rehabilitation therapy.