The Effect of Protein on Calcium Absorption and Gastric Acid Production

• Status: Completed
• Trial end date: 2008-05-01
• Target enrollment: 0
• Participant gender: All

Summary

We have established that dietary protein is an important regulator of intestinal calcium absorption in humans. However, we do not understand the mechanism by which dietary protein is affecting calcium absorption. Therefore, the purpose of this research is to evaluate whether dietary protein-induced changes in gastric acid secretion explain the observed changes in intestinal calcium absorption.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yale University
• Treatments: Calcium, Dietary; Esomeprazole

Criteria

Inclusion Criteria:

• Healthy men and women age 18-45 years

• Caucasian or Asian descent due to increased risk of Osteoporosis

Exclusion Criteria:

• gastrointestinal diseases

• osteoporosis

• diabetes

• hypertension

• liver disease

• thyroid disorders

• kidney disease

• kidney stones

• cancer

• heart disease

• eating disorders

• obesity

• hypogonadism

• amenorrhea

• oligomenorrhea

• abnormal serum FSH or estradiol levels

• birth control medication or other hormone-altering medications

• pregnancy

• Lifestyle factors such as:

• smoking

• excessive exercise (although moderate exercise is allowed)

• prescription medications known to influence vitamin D or calcium metabolism or gastric acid

• excessive body weight change during the past 6 months

• food allergies

• unusual eating habits or medically prescribed diets