The Effect of Restrictive Fluid Management on Cardiac Function and Glycocalyx Degradation

• Status: Not yet recruiting
• Trial end date: 2022-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The study aims to compare the effects of restrictive fluid management on cardiac dysfunction and vascular integrity in septic shock patients. To achieve this, patients with septic shock according to Sepsis-3 criteria admitted to several Intensive Care Units in Sweden and Denmark will be randomized to receive restrictive respectively standard fluid therapy. Blood test from these patients will be analyzed for several biomarkers of cardiac function and glycocalyx degradation. Echocardiography will also be performed to further investigate cardiac function.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Karolinska Institutet
• Treatments: Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Patients with septic shock according to the Sepsis-3 criteria who have received at least 1 L of IV fluid in the 24 hours before screening

Exclusion Criteria:

• Patients who have had septic shock for more than 12 hours at the time of screening

• Patients who have life-threatening bleeding

• Patients with acute burn injury >10% of the body surface area

• Pregnant patients

• Patients in whom consent cannot be obtained