The Effect of Salmeterol on Eosinophil (EOS) Function

• Status: Completed
• Trial end date: 2008-01-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is designed to test the hypothesis that salmeterol use, and not fluticasone use or the combination treatment with fluticasone and salmeterol, is associated with a greater number of sputum eosinophils following antigen challenge and, under these circumstances, the migrating peripheral blood eosinophils are less adherent.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Wisconsin, Madison
• Collaborator: GlaxoSmithKline
• Treatments: Fluticasone; Fluticasone Propionate, Salmeterol Xinafoate Drug Combination; Fluticasone-Salmeterol Drug Combination; Salmeterol Xinafoate

Criteria

Inclusion Criteria:

• 18-55 years of age

• history of asthma symptoms for the previous 6 months

• Forced Expiratory Value (FEV1) >75% of predicted

• positive prick skin test to cat, house dust mite or ragweed

Exclusion Criteria:

• history of life threatening asthma or anaphylaxis

• current smoker

• pregnant or breast-feeding

• evidence of an upper respiratory infection within 4 weeks of screening