The Effect of Selenium Supplementation Among Pediatric Patients With Burns

• Status: Terminated
• Trial end date: 2019-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The selenium status of children with major burns is suboptimal which may increase the incidence of infection. Se requirements during critical illness are not known. Results from this investigation may provide a tool for recommending Se supplements during burn injury.

The hypothesis of this research is that Se supplementation will restore the depressed Se status among children with burn injuries. The secondary hypothesis is that Se status is related to the incidence of infection among pediatric patients with burns.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shriners Hospitals for Children
• Treatments: Selenium

Criteria

Inclusion Criteria:

• Between 1 and 18 years of age admitted to Shriners Burns Hospital

• TBSA burn of > 20%

• Existing IV catheter

• Enrolled into study within 3 weeks of burn injury

Exclusion Criteria:

• < 1 year or > 18 years of age

• < 20% TBSA burn

• No existing IV catheter

• Pre-existing or acute renal disease (creatine > 1.5 mg/dl)

• Pre-existing or acute liver disease (bilirubin > 3)

• Pre-existing or acute thyroid disorders

• Cancer

• AIDS

• Pregnancy (as determined by routine admission labs)