The Effect of Sertindole and Risperidone on Endophenotypic Markers of Schizophrenia

• Status: Terminated
• Trial end date: 2013-07-01
• Target enrollment: 0
• Participant gender: Male

Summary

This comparison is made between the effects of sertindole and risperidone on vulnerability indicators in schizophrenia. More specifically: the effects of these two antipsychotic compounds on basic processing of incoming information is studied. The investigators expect that the newer antipsychotic sertindole to be more effective in restoring information processing in schizophrenia patients than risperidone.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Birte Glenthoj
• Collaborator: Icahn School of Medicine at Mount Sinai
• Treatments: Risperidone; Sertindole

Criteria

Inclusion Criteria:

Healthy controls:

• matched by age (+/- 2 years), gender and parental socioeconomic status to patients with schizophrenia.

• age between 18-55 years

• male

• physically and mentally healthy and no daily intake of medicine

• no current substance abuse

Patients:

• patients who fulfill both ICD-10 and DSM IV diagnostic criteria for schizophrenia.

• age between 18-55 years

• male

• patients who need a change in their medication

• diagnosed with schizophrenia within the last 10 years

• not formerly treated with risperidone (Risperdal) or sertindole (Serdolect) where treatment was stopped because of side effects or lack of effect

• physically healthy

• no current substance abuse

Exclusion Criteria:

Controls:

• a history of mental illness in the first degree relatives

• hearing disabilities

• head injury accompanied by unconsciousness for more than 5 min.

• physical illness with a need of daily intake of medicine

• positive screening for drugs of abuse at baseline.

Patients:

• head injury accompanied by unconsciousness for more than 5 min.

• serious medical conditions (more specific: brain diseases and diseases which cause a daily intake of medicine, heart, liver or kidney diseases, diabetes and prolongation of the QTc-interval (or a family history of such) and patients with phenylketonuri)

• abuse of alcohol or medication/ narcotics during the last 6 months or positive screening for drugs of abuse at baseline.

• former treatment with risperidone (Risperdal) or sertindole (Serdolect) where treatment was stopped because of side effects or lack of effect

• hearing disability

• allergy towards the content in the medicine used in the study

• bradycardia (pulse under 50 beats per minute) and QTc>450 ms