The Effect of Sevoflurane on Cerebral CO2 Sensitivity and Systemic Arteries

• Status: Completed
• Trial end date: 2013-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Purpose:

• The purpose of this study is to examine the effect of different carbon-dioxide concentrations on cerebral CO2 sensitivity and the resistance and stiffness of systemic arteries during anesthesia with sevoflurane. Sevoflurane is a widely and commonly used inhalational anaesthetic, that is mainly used for the maintenance of general anesthesia.

• Changes in the velocity of cerebral blood flow and arterial stiffness due to the different exhaled carbon-dioxide concentrations will allow us to conclude how sevoflurane affects these parameters during the course of the narcosis.

Instruments:

• An ultrasound device called transcranial doppler (TCD) is used to measure the velocity of blood flow within a main artery located inside the skull.

• A tonometry device named SphygmoCor is used to assess the pressure wave proceeding in the radial artery, from which the stiffness of the systemic vessels can be concluded.

Measurements:

• Examinations with the ultrasound and tonometry devices are carried out once before the operation, three times during the intervention, with different exhaled CO2 values and once after the operation is completed.

Hypothesis:

• Sevoflurane alters cerebral carbon-dioxide sensitivity and the stiffness of systemic arteries.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Debrecen
• Treatments: Sevoflurane

Criteria

Inclusion Criteria:

• Above the age 18

• American Society of Anesthesiologists (ASA) physical classification I. or II.

• Patients undergoing elective varicotomy or inguinal hernioplasty in general anesthesia

Exclusion Criteria:

• Patients with cerebral, cardiac or systemic vascular disorders (hypertension, diabetes)

• Patients receiving medication that affects the blood vessels (antihypertensive, antidiabetic, antiarrhythmic medications)