The Effect of Sirolimus on the Pharmacokinetics of Tacrolimus

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to understand whether the pharmacokinetics of tacrolimus is influenced by the concurrent use of sirolimus.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: Everolimus; Mycophenolate mofetil; Mycophenolic Acid; Sirolimus; Tacrolimus

Criteria

Inclusion Criteria:

• De novo kidney transplant patients

• Aged 13 - 65 years

• Having aminotransferase concentrations within 2 times the upper limit of normal

Exclusion Criteria:

• Pregnancy

• Tuberculosis

• Hepatitis B or C carrier status

• Human immunodeficiency virus-positive status

• Retransplantation or multi-organ transplantation

• History of rheumatoid arthritis