The Effect of Spironolactone on Blood Pressure in Type-2 Diabetics With Resistant Hypertension

• Status: Completed
• Trial end date: 2012-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to estimate the effect of spironolactone on blood pressure resistant to therapy in type-2 diabetics.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ib Abildgaard Jacobsen
• Treatments: Spironolactone

Criteria

Inclusion Criteria:

• Age < 75 years

• Type-2 diabetes

• Therapy resistant hypertension (by ABPM)

• Treatment with at least 3 antihypertensives

Exclusion Criteria:

• HbA1c > 10.0

• BP > 180/110 mmHg

• Secondary hypertension

• Intolerance to spironolactone

• Permanent treatment with nonsteroidal antiinflammatory drugs or systemic glucocorticoids

• Total cholesterol 10 mmol/l

• New York Heart Association class III and IV

• Pregnancy or planned pregnancy

• Psychiatric disease

• Malignant disease

• Insufficient adherence