The Effect of Sugammadex During Transcranial Electrical Motor Evoked Potential Monitoring in Spinal Surgery
Status:
Completed
Trial end date:
2020-12-31
Target enrollment:
Participant gender:
Summary
Transcranial motor evoked potential (TcMEP) monitoring is conventionally performed during
neurosurgical procedures without or with minimal neuromuscular blockade (NMB) because of its
potential interference with signal interpretation. However, full blockade offers increased
anesthetic management options and facilitates surgery. Here, investigators want to assess the
effect of Sugammadex during TcMEP in adult patients. Sugammadex is designed to encapsulate
rocuronium and reverse rocuronium-induced neuromuscular blockade. 64 patients undergoing
thoracic or lumbar spinal surgery will be randomly allocated into sugammadex group or control
group under a ratio of 1 to 1. Patients will receive either continuous infusion of rocuronium
to produce blockade maintained at least two twitches in Train-of-Four (TOF), rocuronium
infusion will be discontinued and 2 mg/kg of sugammadex will be infused while dura opening in
sugammadex group. Whereas no muscle relaxant will be given after anesthetic induction in
control group. The primary aim of this study is to compare mean value of amplitudes of TcMEPs
in abductor pollicis brevis muscles of both upper extremities 5 minutes after dura opening.