The Effect of Sumatriptan and Placebo Injection on Cilostazol Induced Headache

• Status: Completed
• Trial end date: 2018-09-01
• Target enrollment: 0
• Participant gender: All

Summary

To develop a pragmatic migraine model the investigators will induce headache in patients with migraine without aura with a phosphodiesterase inhibitor (cilostazol). If the headache responds to sumatriptan injection, the model can be used to test new drug candidates.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Danish Headache Center
• Treatments: Cilostazol; Sumatriptan

Criteria

Inclusion Criteria:

• Migraine patients who meet IHS criteria for migraine with or without aura of both sexes

• 18-70 years

• 45-95 kg.

Exclusion Criteria:

• Any other type of headache then migraine without aura (except episodic tension-type headache < 1 day per week)

• Serious somatic or psychiatric disease

• Pregnancy

• Intake of daily medication (except oral contraceptives)

• Triptan non-responders