The Effect of Surgically Induced Weight Loss on Endocrine Function, Cardiovascular Function and Body Composition

• Status: Terminated
• Trial end date: 2010-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is being conducted to evaluate changes in sugar, metabolism, heart function and changes in body composition as patients lose weight following bariatric surgery. The investigators will compare improvements of the above changes as a function of the four different types of bariatric surgery. The investigators believe the most beneficial and safest procedure will be the Roux-en-Y.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Johns Hopkins University
• Treatments: Glucagon; Glucagon-Like Peptide 1

Criteria

Inclusion Criteria:

• Male and female volunteers 21-65 years.

• BMI > 40.

• Preoperative hematocrit level of at least 34% for women and 38% for men.

• Postoperative hematocrit level of at least 34% for women and 36% for men.

Exclusion Criteria:

• Volunteers whose hematocrit level does not meet the above criteria.

• Pregnant and or lactating females.