The Effect of Ticagrelor With or Without Atorvastatin on Endothelial Function in Healthy Males
Status:
Completed
Trial end date:
2017-03-01
Target enrollment:
Participant gender:
Summary
To test the effect of atorvastatin or placebo in combination with ticagrelor on ACh-induced
vasodilatation of the forearm resistance vasculature as assessed by forearm blood flow (FBF)
measurement before and 10 min after a 20 min forearm ischemia. The area under the dose-effect
curve (AUC) of different ACh doses will be calculated and compared between treatment groups
(atorvastatin + ticagrelor vs. placebo + ticagrelor) and different time points (pre-ischemia
vs. post-ischemia).