The Effect of Ticagrelor or Clopidogrel on Endothelial Function During Acute and Chronic Treatment
Status:
Completed
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
To investigate if treatment with ticagrelor can mitigate the transient loss of
endothelium-dependent vasodilatation of the resistance vasculature following a short period
of ischemia, compared with clopidogrel at standard clinical doses. The effect of ticagrelor
or clopidogrel will be studied after a loading dose and after a two weeks period of regular
intake on FBF in response to the vasodilators acetylcholine or nitroglycerin before and 10
min after a 20 min forearm ischemia, respectively.