The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

After surgical procedures, interventions to reduce postoperative pain and bleeding are of great importance. In this study, the effect will be investigated of smearing common drugs, which are designed for injection, directly onto the raw wound surface (topical application) created during surgery. Topical application allows a small amount of drug to reach a large wound area, higher drug concentration in the exposed wound surface but very low concentration in the body, and no risk of injury from needles. Although beneficial effects of such an easy and low-cost intervention would be expected, the investigators have found no previous reports on blinded and controlled studies.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St. Olavs Hospital
• Treatments: Bupivacaine; Epinephrine; Epinephryl borate; Racepinephrine; Tranexamic Acid

Criteria

Inclusion Criteria:

• Patients undergoing unilateral simple mastectomy

• patients undergoing bilateral symmetric breast surgery

Exclusion Criteria:

• pregnancy

• A history of former thromboembolic events (to receive TXA)

• cardiovascular disease (to receive adrenaline)