The Effect of Topical Curcumin Versus Topical Corticosteroid on Management of Oral Lichen Planus Patients

• Status: Unknown status
• Trial end date: 2020-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Introduce a new anti-inflammatory and antioxidant paste preparation (curcumin paste) in the management of Oral lichen planus.

• Assess the efficacy of this preparation on pain, clinical parameter and the level of IL-33 in saliva.

• Compare the outcome of new preparation with the gold standard treatment (corticosteroids).

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Curcumin; Triamcinolone; Triamcinolone Acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide; Turmeric extract

Criteria

Inclusion Criteria:

• Patients who will be clinically diagnosed as having atrophic &/or erosive oral lichen planus.

• Patients with controlled diabetes and/or controlled hypertension will be included in the study.

• Patients with no history of taking corticosteroids for the last 6 months

• Patients who agrees to take medication.

Exclusion Criteria:

• Pregnant and lactating ladies.

• Patients with history of topical steroids during last 2 months & systemic steroids during last 6 months.

• Patients with recent dental filling associated with the lesion or associated with recent drug administration.

• Patient with uncontrolled diabetes, uncontrolled hypertension, or those with positive HCV ab or HBs Ag.