The Effect of Topical Tranexamic Acid on Bleeding and Seroma Formation in After Undergoing Mastectomy
Status:
Completed
Trial end date:
2018-10-01
Target enrollment:
Participant gender:
Summary
After surgical procedures, interventions to reduce postoperative bleeding are of great
importance. In this study, the effect will be investigated of smearing tranexamic acid, which
is designed for injection, directly onto the raw wound surface (topical application) created
during surgery. Topical application allows a small amount of drug to reach a large wound
area, higher drug concentration in the exposed wound surface but very low concentration in
the body, and no risk of injury from needles. The researchers have recently shown that
topically applicated tranexamic acid reduces bleeding in women who had two-sided breast
reduction surgery. Now it will be studied whether topically applicated tranexamic acid
reduces bleeding after breast surgery for breast cancer.
After surgery for breast cancer patients may also experience problems with long lasting
seroma. Therefore it will at the same time be investigated whether topical tranexamic acid
reduces the development of seroma in these patients.