The Effect of Topical Treatment With Combigan Compared to Timolol and Brimonidine on Pupil Diameter

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study we will explore the combined effect of Brimonidine and Timolol 0.5% (Combigan) eye drops on pupil dilation. It is a well studied phenoma that Brimonidine and a miotic effect on the pupil, however the combined effect of alpha agonist and beta blocker has not been studied.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Carmel Medical Center
• Treatments: Brimonidine Tartrate; Brimonidine Tartrate, Timolol Maleate Drug Combination; Ophthalmic Solutions; Timolol

Criteria

Inclusion Criteria:

• Healthy adults subjects with no ocular pathology

• Non pregnant women

• Normal pupil response

Exclusion Criteria:

• Chronic topical treatment

• Systemic medication affecting autonomic nerve system

• History of intra-ocular surgery

• Irregular pupil

• History of ocular neurological or severe cardio-vascular disease