The Effect of Total Intravenous Anesthesia With Propofol on Postoperative Nausea and Vomiting in Patients Undergoing Robot-assisted Laparoscopic Radical Prostatectomy

• Status: Completed
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

To maximize the surgical visual field, Robot-assisted laparoscopic radical prostatectomy (RLRP) usually requires the patient to be positioned in a steep trendelenburg position in combination with prolonged intraperitoneal carbon dioxide (CO2) insufflation and increased intrabdominal pressure. Insufflations of CO2 during laparoscopic surgery, which causes stretch and irritation of the peritoneum, is known to play an important role in postoperative nausea and vomiting (PONV). In addition, prolonged pneumoperitoneum increases the risk for PONV. PONV can cause patient discomfort and prolong post anaesthesia care unit (PACU) stay. In addition, the patient with PONV is also predisposed to severe complications such as aspiration pneumonia, increased wound dehiscence, delayed recovery, prolonged hospital stay, and eventually increased medical cost.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Anesthetics; Propofol

Criteria

Inclusion Criteria:

• Patients undergoing RLRP, ASA physical status I or II, age 50 to 70.

Exclusion Criteria:

• Emergency operation.

• patients with motion sickness or PONV history to control anticipated risk of PONV.

• Patients with antiemetic use within 24 hours before surgery.

• Patients with regular corticosteroid use.

• Patients with chemotherapy within 4 or radiotherapy within 8 weeks.

• Patients with allergy to any of the study drugs.

• Patients with liver dysfunction, confirmed renal impairment, or obesity (body mass index > 35 kg/m2).