The Effect of Tranexamic Acid (TXA) on Visualization During Shoulder Arthroscopy
Status:
Enrolling by invitation
Trial end date:
2020-12-31
Target enrollment:
Participant gender:
Summary
Tranexamic acid has seen an increase in use over the past decade in hip and knee arthroplasty
as well as spine surgery with more recent use seen in total shoulder arthroplasty (TSA). The
mechanism of action of TXA is as a lysine analogue that competitively inhibits the conversion
of plasminogen to plasmin thus resulting in its antifibrinolytic activity. Investigators have
showed that compared with placebo TXA had a statistically significant effect on blood and
postoperative hemoglobin levels in TSA. To date there are no studies investigating the effect
of TXA in arthroscopy of any kind or studies examining the ability of TXA to aid in surgeon
visualization in arthroscopic procedures. The investigators of this study will use change in
pump pressure as a surrogate objective measure for surgeon visualization. The hypothesis is
that participants who receive TXA will have a lower change in pump pressure compared to
participants who do not receive TXA.