The Effect of Type 2 Diabetes and Dietary Regulation on VLDL1-and VLDL2-triglyceride Metabolism

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

In this study the investigators wish to compare Very Low-Density Lipoprotein (VLDL) kinetics in type 2 diabetic males and healthy males postabsorptive and during hyperinsulinemia. The kinetics is obtained using an ex-vivo VLDL1- and VLDL2-triglyceride labeling technique. The investigators hypothesis is that the investigators will find an increased VLDL1 production in type 2 diabetic males, which is not lowered by hyperinsulinemia. Also the investigators wish to investigate the influence of diet on VLDL1 and VLDL2 production in healthy males, where the investigators expect less variance in VLDL production when the subject is given an isocaloric diet.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Aarhus
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• patients with type 2 diabetes during at least six month or healthy subjects

• male

• BMI 25-36 kg/m2

• age 35-65

Exclusion Criteria:

• other diseases (hypertension and hypercholesterolemia tolerated)

• Insulin treatment

• alcohol abuse

• smoking

• medication affecting lipid metabolism apart from statins and antihypertensive drugs paused 2 weeks prior to the study day.

• participation in studies involving radioactive isotopes or larger x-ray investigations within the last six month.

• blood donation within three month.