Overview

The Effect of Ultra-low-dose Naloxone on Remifentanil-induced Postoperative Hyperalgesia - A Randomized Controlled Study

Status:
Completed

Trial end date:
2015-04-01

Target enrollment:
0

Participant gender:
All

Summary

High-dose remifentanil infused intraoperative ironically results in postoperative hyperalgesia. Ultra-low dose nalxone is demonstrated to prevent these opioid-induced hyperalgesia in animal model. In this clinical trial in patients undergoing general anesthesia with remifentanil, we evaluate the effects of ultra-low-dose naloxone on remifentanil-induced hyperalgesia

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Seoul National University Hospital

Treatments:

Naloxone
Remifentanil

Criteria

Inclusion Criteria:

- patients who are scheduled to undergo elective thyroidectomy

Exclusion Criteria:

- consent refusal, obesity, pregnancy, hx. of thyroid surgery, neurological disorders,
psychiatric disorders, hx. of drug abuse or chronic use of opioids or sedative drugs,
intake of any analgesic drug within 12h before surgery.