The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure

• Status: Completed
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: All

Summary

In this prospective study, the investigators aimed to evaluate the effects of improved hyperuricemia, a minor cardiovascular risk factor, on endothelial dysfunction in patients with chronic kidney disease.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Istanbul University
• Treatments: Allopurinol; Uric Acid

Criteria

Inclusion Criteria:

• Laboratory finding of hyperuricemia

• Patients between ages of 18 and 60 years

• Non-diabetic patients

• Creatinine clearance values between 20 and 60 mL/min/1.73 m2

Exclusion Criteria:

• Low (< 20 ml/min/1.73 m2) creatinine clearance,

• Patients with diabetes mellitus, ischemic heart disease, acute coronary syndrome, congestive heart failure (CHF) (New York Heart Association class II or greater), valvular heart disease and a history of cerebral infarction or transient ischemic attack.

• Patients taking urate lowering medication (allopurinol and probenecid)