The Effect of Various Types of the Renin-angiotensin-aldosterone System Blockade on Proteinuria

• Status: Completed
• Trial end date: 2011-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The main purpose of the study is to compare the effects of three different types of RAAS blockade on 24 hours proteinuria in patients with non-diabetic chronic kidney disease.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Gdansk
• Treatments: Eplerenone; Spironolactone; Telmisartan

Criteria

Inclusion Criteria:

• age 18-65 years

• chronic non-diabetic proteinuric nephropathy

• chronic kidney disease stage 1-3

• stable proteinuria above 500 mg/24 hours

• blood pressure above 125/75 mmHg and below 150/95 mmHg

• no steroids or other immunosuppressive treatment for a minimum of six months before the study

Exclusion Criteria:

• unstable coronary heart disease

• decompensated congestive heart failure in the previous 6 months

• episode of malignant hypertension or stroke in the history

• diabetes

• creatinine clearance below 30 ml/min

• pregnancy