The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study
Status:
Completed
Trial end date:
2019-08-01
Target enrollment:
Participant gender:
Summary
Previous studies have demonstrated that venlafaxine significantly improves the language
function of healthy subjects and increase of fMRI activation in cortical language area. This
study was designed to investigate the relationship between venlafaxine on the cortical
language functional reorganization and clinical language improvements in the stroke patients
with subcortical aphasia.
It is a randomized, controlled, single-blind, longitudinal trial which has approved by the
ethics committee of Guangzhou General Hospital of Guangzhou Military Command, and all
patients and their guardian should sign an informed consent. The patients will divide into
the venlafaxine group and the control group according to the principle of randomization
(random number table). The patients in the venlafaxine group begin to take a venlafaxine
hydrochloride capsule after enrollment ( each containing venlafaxine 75mg), qd, until 4 weeks
after randomization, and the control group do not. Assessments of language functional
behavior and examines of functional magnetic resonance imaging (fMRI) should be performed on
the first days (V1), 28±3 days (V2) and 90±3 days (V3) after randomization.
Through all this procession, we expect improve the language function of participants in
experiment and clarify its mechanism,the research may help develop a new treatment for other
patients with similar conditions.
Phase:
N/A
Details
Lead Sponsor:
Guangzhou General Hospital of Guangzhou Military Command