The Effect of Vitamin D3 on Postoperative Pain in Patients Undergoing Craniotomy

• Status: Completed
• Trial end date: 2018-11-30
• Target enrollment: 0
• Participant gender: All

Summary

Vitamin D is a hormone mainly synthesized in the skin in the presence of sunlight. Like other hormones, vitamin D plays a role in a wide range of processes in the body. Some studies have shown vitamin D has anti-inflammatory effects in the body by reducing the release of pro-inflammatory cytokines and suppressing T-cell responses. Therefore, vitamin D may be effective on reduce pain by such mechanisms. In this trial patients with brain tumor under craniotomy will receive a single high dose vitamin D compared to the control group.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shahid Beheshti University
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Written informed consent of patient or legal representative

• 25(OH)D level below 20ng/dL

Exclusion Criteria:

• Other trial participation, including previous participation in the pilot trial

• Pregnant or lactating women

• Hypercalcemia

• Hyperphosphatemia

• Tuberculosis

• Sarcoidosis

• History of nephrolithiasis

• History of hyperparathyroidism

• Medications that interfere with vitamin D metabolism

• Renal Insufficiency