The Effect of Zinc, β-carotene, and Vitamin D3 in Preterm Delivery Through Placental MyD88, TRIF, NFkB, and IL-1β

• Status: Completed
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study is a controlled trial which compares the effect of zinc, beta-carotene, and Vitamin D3 supplementation in pregnant women which has preterm birth. The measured outcome is zinc, vitamin A, and 25(OH)D level in serum and placenta, MyD88, TRIF, NFκB, and IL-1β levels in placenta.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Indonesia University
• Treatments: BB 1101; Beta Carotene; Carotenoids; Cholecalciferol; Dexamethasone; Dexamethasone acetate; Ergocalciferols; Nifedipine; Picolinic acid; Vitamin D; Vitamins; Zinc

Criteria

Inclusion Criteria:

• Pregnant women who has preterm birth in 26-36 weeks gestational age

Exclusion Criteria:

• Multiple pregnancy

• Drug allergy

• Intra Uterine Growth Retardation (IUGR) is detected

• Congenital malformation in fetus was found

• Preterm Premature Rupture of Membrane (PPROM)

• Maternal complication such as gestational hypertension, preeclampsia, gestational diabetes mellitus, heart disease, infection, and autoimmune disease