The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders
Status:
Unknown status
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
The supplementation of Dehydroepiandrosterone (DHEA) has been used in some centers for
patients with previous poor ovarian reserve and response in an attempt to improve pregnancy
outcomes. However, there still has controversy on the clinical effect on the 75mg/d for the
use,especially in Asian people. Whether the double dosage of DHEA in patients with poor
ovarian reserve and response in China can improve the IVF outcome with little side effect is
unknown.
The aim of this randomized controlled study is to compare the effect of a higher dose (150mg
daily) and a standard dose (75mg daily) of DHEA on the number of oocytes obtained in poor
ovarian responders. The effect of DHEA action on the cumulus cells will be examined.