The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The supplementation of Dehydroepiandrosterone (DHEA) has been used in some centers for patients with previous poor ovarian reserve and response in an attempt to improve pregnancy outcomes. However, there still has controversy on the clinical effect on the 75mg/d for the use,especially in Asian people. Whether the double dosage of DHEA in patients with poor ovarian reserve and response in China can improve the IVF outcome with little side effect is unknown.

The aim of this randomized controlled study is to compare the effect of a higher dose (150mg daily) and a standard dose (75mg daily) of DHEA on the number of oocytes obtained in poor ovarian responders. The effect of DHEA action on the cumulus cells will be examined.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: ShangHai Ji Ai Genetics & IVF Institute
• Treatments: Dehydroepiandrosterone

Criteria

Inclusion Criteria:

1. age<45 years,

2. subfertility >1 year, and

3. A previous POR (≤3 oocytes with a conventional stimulation protocol of at least 150 IU FSH per day); or

4. An abnormal ovarian reserve test (i.e. AFC ≤5-7 follicles or AMH ≤0.5-1.1 ng/ml).

Exclusion Criteria:

Patients were excluded if they:

1. had a history of ovarian cystectomy or oophorectomy,

2. had received cytotoxic chemotherapy,

3. had received pelvic irradiation, or

4. had a history of taking testosterone or DHEA supplementation