The Effect of a Selective Serotonin Reuptake Inhibitor on Gait, Balance, and Bone Metabolism in Older Adults

• Status: Completed
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the effects of sertraline treatment of depression in older adults on gait stability, balance recovery reactions, and markers of bone metabolism. This is a pilot study that will determine feasibility and generate hypotheses for a larger definitive study.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Health Network, Toronto
• Treatments: Serotonin; Serotonin Uptake Inhibitors; Sertraline

Criteria

Depressed group

Inclusion Criteria:

• Clinical diagnosis of Major Depression

• English-speaking

• If currently on an antidepressant, willing to undergo a 2 week washout.

Exclusion Criteria:

• Lifetime bipolar disorder

• Current psychotic disorder or substance use disorder

• Dementia

• Poor baseline mobility or baseline severe gait disorder

• On treatment with fluoxetine or mood stabilizer

• Severe renal impairment, bleeding disorder, recent gastric bleeding or hemorrhagic stroke in past 3 months

• Poor response or serious adverse event with sertraline in the past.

Comparison group

Inclusion Criteria:

• English-speaking

Exclusion Criteria:

• Lifetime diagnosis of depression or dementia

• Currently on antidepressant medication or mood stabilizer

• Poor baseline mobility or baseline severe gait disorder