The Effect of an Antibiotic on the Production of Uremic Toxins by the Gut Microbiome
Status:
Completed
Trial end date:
2018-08-18
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine if multiple doses of vancomycin over the course of
3 months will perturb the intestinal flora (microbiome) and result in reduced serum
concentration of the uremic toxin indoxyl sulfate and p-cresyl sulfate. The design of the
study will permit investigators to assess the variability of serum uremic retention solute
concentrations with and without antibiotic over a three-month period.
Phase:
Phase 2
Details
Lead Sponsor:
New York University School of Medicine NYU Langone Health