The Effect of an Opioid on the Lower Esophageal Sphincter During Anesthesia Induction

• Status: Completed
• Trial end date: 2010-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the effects of adding an opioid (alfentanil) during anesthesia induction with respect to the barrierpressure in the esophagogastric junction.

The secondary aim was to investigate whether the effect of cricoid pressure influences the barrierpressure.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Region Örebro County
• Treatments: Alfentanil; Anesthetics

Criteria

Inclusion Criteria:

• Healthy volunteer 18-40 years old

• Informed,signed and dated consent

Exclusion Criteria:

• Pharyngoesophageal dysfunction

• Gastro/intestinal-,cardiovascular-,lung- or neurologic disease

• Ongoing medication

• Allergy to alfentanil, propofol, soya or peanuts

• Pregnancy or breast-feeding

• BMI>30

• Participation in other clinical trial -ongoing or during last 30 days.