The Effect on Decreasing Chemotherapeutic Toxicity and Increasing Anti-tumor Effect of Chinese Herbs Based on Syndrome Differentiation

• Status: Unknown status
• Trial end date: 2020-01-01
• Target enrollment: 0
• Participant gender: All

Summary

To study the effect on decreasing chemotherapeutic toxicity and increasing anti-tumor treatment of Chinese Herbs based on syndrome differentiation

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Criteria

Inclusion Criteria:

• Histology and cytology diagnosed IIIB or IV non-small-cell lung cancer (NSCLC) and untreated; Age > 18 ages

• Sex unlimited; ECOG (Eastern Cooperative Oncology Group) fitness score (Performance status, PS)≤2.

• White blood cell count ≥ 3 x 10E9 / L, neutrophils ≥1 x 109 p/L, hemoglobin≥80 g/L , platelet ≥100 x 10E9 / L

• ALT, AST, normal or less than 2 times, bilirubin is normal

• Serum level in the normal range;Thr ecg is normal

• Expected survival time≥ 3 months or more;

• Agreed to the treatment combined traditional Chinese medicine with western medicine

Exclusion Criteria:

• Engaged in other clinical subjects

• Pregnant or lactating women, women in childbearing age refuse contraceptives during the trail

• Severe pneumonia, tuberculosis, lung abscess, myocarditis and other malignant tumor

• Severe damage of heart, liver and kidney (cardiac function grade 3 ~ 4, ALT and/or AST 2 times more than normal , Cr more the normal limit)

• Mental illness, Refused to partner; Cannot obtain informed consent