The Effectiveness of Enough Steroids as Inducement Therapy in Minimal Change Disease-like IgA Nephropathy

• Status: Completed
• Trial end date: 2012-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a single center,prospective,no-controlled clinical trial

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nanjing University School of Medicine
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate; Prednisone

Criteria

Inclusion Criteria:

• Female or male patients aged between 18 to 65 years

• Renal biopsy was used to diagnose IgA nephropathy

• Patients with 24h proteinuria 3.5g and serum albumin concentration lower than 30g/L

Exclusion Criteria:

• Patients with serum creatinine ≥ 3 mg/dl or eGFR < 30ml/min per 1.73 m2

• urine RBC > 1 million/ml

• Patients who have received treatment of enough steroids for more than 12 weeks

• patients with secondary IgA

• Patients who have impaired liver function,with ALT/GPT or AST/GOT twice more than the normal upper limit or who have active hepatitis

• Patients with 2 type diabetes or obesity, whose BMI is more than 28kg/m2