The Effectiveness of High-dose Intravenous Vitamin c With Very Low Carbohydrate Diet for Terminal Colon Cancer Patients

• Status: Not yet recruiting
• Trial end date: 2022-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose is to evaluate the effectiveness of high dose intravenous vitamin C (IVC) therapy plus very low carbohydrate diet (VLCD) for stage IV colon cancer (with KRAS and BRAF mutation ) with or without chemotherapy.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: Ascorbic Acid; Vitamins

Criteria

Inclusion Criteria:

• stage IV colon cancer

• with KRAS and BRAF mutation

Exclusion Criteria:

• G-6-PD deficiency,

• metastatic kidney disease,

• obstructive uropathy,

• nephrotic syndrome,

• under other alternative medicine treatment or intravenous vitamin treatment,

• pregnant or lactating women,

• impaired renal function with a serum creatinine ≥ 132.6µmol/L(1.5 mg/dL)

• significant fluid retention(pleural effusion, ascites, lower leg edema),

• terminal heart failure,

• incapability to make decision,