The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis
Status:
Completed
Trial end date:
2006-04-01
Target enrollment:
Participant gender:
Summary
This study will compare a single dose of oral dexamethasone to placebo in a multicenter,
randomized, double blind trial of infants aged 2 to 12 months with first-time bronchiolitis
(defined as wheezing within 7 days of onset). This is given as additional therapy beyond any
other routine therapy used at that center. No current standard therapy is withheld, and no
additional tests or other treatments are part of the study.The primary hypothesis is that
dexamethasone will be more effective than placebo in preventing hospital admission. The
secondary hypotheses are that dexamethasone will decrease respiratory scores and possibly the
duration of the disease when compared to placebo, and that dexamethasone will be as safe and
as well tolerated as placebo.
Phase:
Phase 4
Details
Lead Sponsor:
University of Utah
Collaborators:
Boston Children's Hospital Boston Children’s Hospital Children's Hospital Medical Center, Cincinnati Children's Hospital of Michigan Children's Hospital of Philadelphia Children's National Research Institute Children's Research Institute Columbia University Helen DeVos Children's Hospital Howard County General Hospital Hurley Medical Center Johns Hopkins University New York University School of Medicine NYU Langone Health University of California, Davis University of Maryland University of Maryland, College Park University of Rochester Washington University School of Medicine Women & Children's Hospital of Buffalo