The Effectiveness of Two Anti-HIV Treatments in HIV-Infected Patients
Status:
Completed
Trial end date:
1995-05-01
Target enrollment:
Participant gender:
Summary
To determine the effects of zidovudine (AZT) alone and in combination with didanosine (ddI)
on viral load in the lymphoid tissue and blood of antiretroviral-naive, HIV-infected patients
with CD4 counts greater than or equal to 550 cells/mm3.
Recent studies have shown that during the asymptomatic phase (clinical latency) of HIV
infection, there is an extraordinarily large number of infected CD4+ lymphocytes and
macrophages throughout the lymphoid system, both in latent and productive states. These
findings support the belief that early intervention therapy with reverse transcriptase
inhibitors could prolong the clinical latency period.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)