The Effects of Acute Administration of Bupropion on Neural Substrates Underlying Hedonic Capacity

• Status: Completed
• Trial end date: 2007-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to evaluate the effects of a single-dose of Wellbutrin XL (bupropion hydrochloride) on reward processing.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Affective Neuroscience Laboratory
• Collaborator: Massachusetts General Hospital
• Treatments: Bupropion

Criteria

Inclusion Criteria:

• Absence of medical, neurological, and psychiatric illness (including alcohol and substance abuse)

• Non-Smoker

• Right-handed (Chapman and Chapman 1987)

• Ability to provide informed consent

Exclusion Criteria:

• Predisposition to seizure (e.g. family history of a seizure disorder, history of head trauma) or current use of medications that lower the seizure threshold

• History or current diagnosis of anorexia or bulimia

• Alcohol or substance abuse within the past year

• Current usage of Wellbutrin or Zyban or other drugs that contain bupropion

• Recent discontinuation of alcohol or sedatives (including benzodiazepines)

• Use of (in the last 2 weeks) medications that may have antidepressant properties (ex. some herbal supplements)

• Known allergies to bupropion

• Currently lactating, pregnant or believe you are likely to be pregnant (enrolled subjects who are not using reliable contraception and have engaged in sexual intercourse since their last menstrual period will be given a self-administered pregnancy test.)

• Left-handed/ambidextrous

• Evidence of neurological illness

• Serious suicide or homicide risk

Concomitant medications other than those listed in the exclusion criteria will be considered on an individual basis. Oral contraceptives will be allowed.