The Effects of Antihistamines on Pre-Pulse Inhibition

• Status: Completed
• Trial end date: 2012-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the investigators research is to test whether problems people have with processing their senses (feeling overwhelmed, distracted or upset by sounds and other stimuli) can be lessened by meclizine, a drug found in many over the counter antihistamines, which are medicines used for things like allergies, sleep problems, or the common cold.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Duke University
• Collaborator: Wallace H. Coulter Foundation
• Treatments: Dimenhydrinate; Histamine Antagonists; Histamine H1 Antagonists; Meclizine

Criteria

Inclusion Criteria:

• 18-40 males or females

• Startle response >0.5

• PPI < 32

• CO level <8ppm

Exclusion Criteria:

• Tobacco or nicotine use within 2 weeks of screening

• Current or history of a neurological disorder of neurological event

• Negative response to antihistamine use in past

• ECT treatment in the past 6 months

• Current or past history of manic or hypomanic episodes (SCID-I)

• Current or history of psychotic disorder

• Current alcohol or substance abuse/dependence

• Positive urine drug test

• CO level of >8ppm

• Startle <0.5 & overall PPI >32 (assessed during study)

• Significant hearing problem