The Effects of Aspirin and Acetaminophen on the Stomach in Healthy Volunteers
Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
Aspirin is a medication commonly used to relieve minor pains. Aspirin has also been used to
prevent heart attacks and strokes. Aspirin, however, can also cause damage to the stomach
and/or intestinal lining leading to the development of erosions ("small sores") and/or ulcers
("large sores"). Erosions may cause bleeding ("bleeding ulcers") and/or perforations ("holes
in the stomach"). Acetaminophen, often referred by the brand name, Tylenol, is also used to
treat minor pains but is not commonly recognized to cause damage to the stomach lining.
Many patients often take both of these medications together. While the effects on the stomach
lining of each medication, when used alone, are known, the effects of both medications, when
used together, are not.
The purpose of this study is to show whether or not the collective effects of both aspirin
and acetaminophen, when used together, increase the damage on the stomach lining when
compared to either medication alone.