The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Two-Week Treatment Period

• Status: Completed
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to compare the safety and efficacy of azithromycin ophthalmic solution, 1% versus placebo over a two-week treatment period.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.
• Treatments: Azithromycin; Ophthalmic Solutions; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Have best corrected visual acuity in both eyes of at least +0.7 or better

• If female, are non-pregnant or non-lactating

• Have a current diagnosis of blepharitis in one or both eyes

Exclusion Criteria:

• Have lid structural abnormalities

• Have suspected ocular fungal or viral infection

• Have practiced warm compress therapy within 14 days prior to Visit 2

• Unable to withhold the use of contact lenses during the treatment or follow-up periods

• Unable to withhold the use of ocular cosmetic products within 24 hours prior to study visits

• Have had penetrating intraocular surgery within 90 days prior to Visit 2

• Have had ocular surface surgery within the past year prior to Visit 2

• Have a serious medical condition which could confound study assessments