The Effects of Bariatric Surgeries on Glucose Metabolism

• Status: Recruiting
• Trial end date: 2023-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cedars-Sinai Medical Center; The University of Texas Health Science Center at San Antonio
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Atropine; Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Hypoglycemic RYGB patients with documented blood glucose level <50 mg/dl

• Asymptomatic individuals with bariatric surgery

• Healthy non-surgical patients with no personal history of diabetes

• Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center

Exclusion Criteria:

• Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin <11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies;

• RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea.

• Healthy non-surgical patients with personal history of diabetes

For administration of atropine, the following exclusions also apply:

• History of glaucoma

• Uncontrolled hypertension (any subjects with BP>140/90 and history of dyslipidemia

• Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)

• Myasthenia gravis

• Brain pathology

• Enlarged prostate in men