Xenin-25 and glucose-dependent insulinotropic polypeptide (GIP) are hormones produced in the
intestine that are released into the blood immediately after ingestion of a meal. Together,
these 2 hormones increase insulin release and reduce blood glucose levels. Xenin-25 works by
increasing acetylcholine release in pancreatic islets. This study will determine if a
Bethanechol, a drug that is similar to acetylcholine, also increases insulin release and
reduces blood glucose levels after ingestion of a mixed meal.
Phase:
Phase 1
Details
Lead Sponsor:
Washington University School of Medicine
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)