The Effects of Blood Pressure Reduction on Cerebral Perfusion and Cognition in the Elderly Population

• Status: Unknown status
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if a reduction in systolic blood pressure induced by anti-hypertensive medication results in changes in cerebral perfusion and cognition in hypertensive elderly. Hypertensive elderly will be treated using open-label anti-hypertensive medication for 8-12 weeks. Changes in cerebral perfusion and cognition will be assessed before and after treatment.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radboud University
• Collaborator: Dutch Heart Foundation
• Treatments: Antihypertensive Agents

Criteria

Inclusion Criteria:

• Age >= 70 years

• Systolic office blood pressure >= 160 mmHg

• Systolic home blood pressure >= 155 mmHg

Exclusion Criteria:

• Diabetes Mellitus

• Atrial fibrillation

• Dementia

• Renal failure requiring dialysis

• Life expectancy of less than 1 year

• Disabling stroke

• Contraindication for MRI or anti-hypertensive medication

• Systolic blood pressure > 220 mmHg